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Semaglutide may be the better starting point if You have moderate weight loss goals (10-15% of body weight)

While these are not directly linked to kidney damage, dehydration (from nausea, vomiting or diarrhea) can worsen kidney function in some individuals
it tells your brain youre full
DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other

Most patients notice improvement within the first few weeks