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Oral glucose tolerance test (OGTT) was initiated, unless otherwise stated, 12 min after pharmacological injections or 15 min after chemogenetic manipulation on a total of n = 30 RD and n = 47 WD mice fasted for 5 h

Growth hormone elevation from sermorelin can impair insulin sensitivity in some patients, potentially opposing semaglutide's insulin-sensitizing and appetite-suppressing benefits

Spacing out Ozempic and thyroid meds might reduce interactions

Maintenance dosing is under-studied but widely practiced

These individuals often show blunted GLP-1 responses after meals, suggesting that improving baseline metabolic health can restore more robust GLP-1 signaling over time (Huber et al., 2024)