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The IGF system comprises of IGF-1 and IGF-2 and their respective receptors, IGF-1 receptor and IGF-2 receptor, as well as six binding proteins, IGFBP1-6
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1-dependent and HIF-1-independent manner in obese mice

ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD)
