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Oxyntomodulin, another endogenous ligand of the GLP-1R and the glucagon receptor and allosteric ligands of the GLP-1R have been reported to exhibit some degrees of G-protein bias at the GLP-1R 31,32

The main sources of GLP-1 in the periphery are epithelial L cells, which are located throughout the intestine and whose density varies along a proximal-to-distal axis, with a limited number of cells in the duodenum, an increasing number in the jejunum, and a greater abundance toward the distal ileum and colon [7]

S., Chao M

This process produces substances that help trigger GLP-1 production