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Description
Clinical Evidence Large-scale trials involving adults with obesity showed: Average weight loss of approximately 14.9 percent with semaglutide Approximately 2 to 3 percent weight loss in placebo groups A majority of participants achieved at least 5 percent weight loss Individual results vary based on adherence, starting weight, and underlying metabolic factors

(Statistics found in a 2022 study)

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Risks, side effects and interactions While effective, GLP-1 drugs can have side effects, such as: Nausea and vomiting Diarrhea or constipation Headache Fatigue Risk of pancreatitis Potential thyroid tumors (in animal studies) Real-world reports suggest GLP-1 side effects may be broader than what is emphasized in clinical trials

Researchers believe several mechanisms may contribute to these observations
