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Here, the authors review the physiological roles of GLP-1, the potential renoprotective mechanisms of incretin-based therapies and the available renal outcome data from clinical trials.

Risk of bias was assessed using an adapted Quality Assessment Tool for In Vitro Studies (QUIN) tool

While some ingredients show limited potential, the evidence remains nuanced and should be interpreted carefully

This process preserves the full molecular spectrum of saffron, including volatile compounds like safranal, which are often lost during conventional extraction methods.Its content is 10 times higher in safranal and 20 times more concentrated in crocins than standard extracts, enhancing the effects of saffron on emotional balance

Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has emerged as a groundbreaking treatment for Type 2 diabetes mellitus (T2DM) and obesity