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While switching, youll want to track the progress towards achieving significant weight loss: body weight and waist circumference (to monitor fat loss and body composition) blood sugar / HbA1c / fasting insulin (for glycemic control) blood pressure and heart rate (some of these medications can raise heart-rate) side-effects: GI symptoms (nausea, vomiting), possible more intense responses with retatrutide your diet, hydration status, and workout/energy levels (as your body adjusts to the new medicine) Regular check-ins (every 4 weeks initially) help your provider catch anything needing adjustment