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These findings emphasize the importance of individualized treatment approaches to optimize both efficacy and tolerability

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In both clinical and preclinical models, upon removal of GLP-1R agonists, body weight rebounds rapidly to its initial level or an even higher level

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He described data on the first generation GLP-1 liraglutide (Saxenda) as breaking the sound barrier of obesity pharmacology. He explained: The results went far beyond anything previously seen, and they captured the industrys attention not only to obesity as a disease but also to its many comorbidities as areas worthy of investment