when were glp 1 agonists discovered The expanding landscape of GLP-1 medicines Evolution of GLP-1 receptor agonists
Description
The key is that GLP-1 RA medications are long-lasting receptor agonists that have an effect lasting much longer than naturally produced GLP-1

Diabetes Metab J 44(6):80218 Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS et al (2022) LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept
doi: 10.1152/ajpregu.00275.2010 123 LiberiniCGKoch-LaskowskiKShaulsonEMcGrathLELipskyRKLhamoRet al
Also, Neves et al

GLP-1 receptor agonists: a clinical perspective on cardiovascular effects
