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The FDA classifies most compounded semaglutide and tirzepatide formulations as Category C medications, meaning animal reproduction studies have shown adverse effects, but controlled human data is absent
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The interaction is so dangerous that the FDA has included a boxed warning, the most serious type of alert, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Other Drug Classes That Cause Drowsiness Any CNS depressant, listed in the above table, can be problematic when used with alprazolam, because they increase the risk of drowsiness, dizziness, being off-balance, and difficulty concentrating
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