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Referral to endocrinology, urology, gynecology, or sexual medicine specialists may be appropriate for complex cases requiring specialized evaluation and management

Key warning signs requiring urgent evaluation include: Postmenopausal bleeding (any vaginal bleeding occurring more than 12 months after the last menstrual period) Bleeding accompanied by fever, unusual vaginal discharge, or pelvic pain suggesting infection Bleeding associated with pregnancy or suspected pregnancy Recurrent spotting that persists for more than two to three menstrual cycles Patients taking tirzepatide who develop abnormal bleeding should undergo a comprehensive gynecological assessment, including detailed menstrual history, pelvic examination, and pregnancy testing for all reproductive-age women regardless of contraceptive use

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The level of average weight loss seen in the trial "has not been previously achieved in phase 3 trials for obesity or overweight and type 2 diabetes," Jeff Emmick, Eli Lilly's senior vice president of product development, said in a statement