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MNs are miniature, needle-like structures typically ranging in size from hundreds of micrometers to a few millimeters in length

If vomiting occurs more than twice per week despite dietary modifications, dose adjustment may be necessary

A prespecified analysis of pooled data from the STEP-HFpEF and STEP-HFpEF DM trials demonstrated that significantly more patients treated with Wegovy 2.4 mg SC once weekly had an improvement of at least one in New York Heart Association (NYHA) functional class compared to those who received placebo (32.6% versus 21.5%, respectively

Research suggests that L-cells are most responsive to nutrients during specific time windows, and that extended fasting periods may enhance L-cell sensitivity