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These scientific breakthroughs coincided with obesity becoming a top global health issue in the past 1520 years, driving a perfect storm for adoption

[DOI] [PubMed] [Google Scholar] 43.Montrose-Rafizadeh C, Avdonin P, Garant MJ, Rodgers BD, Kole S, Yang H, et al

Investigating differential responses based on patient demographics, genetic profiles, and specific pain conditions will also be crucial in developing personalized treatment strategies, thereby optimizing the therapeutic benefits of GLP-1R agonists for diverse patient populations

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Future research and clinical implications Current studies focus on short-term efficacy, but gaps persist regarding the impact on reproductive health, hormonal balance, and bone density over prolonged use