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Novo Nordisks Peter Johannsen, MD, highlighted the biological signals observed and acknowledged the clinical limitations: subgroup analyses did not reveal meaningful benefit, and any potential responder group would be very small

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The 46-year-old actress has since lost more than 40 pounds.

AN is obesity's metabolic bookend. That connection explains why GLP-1 agonists carry serious risks for those predisposed to AN and with at least one in eight American adults now taking these drugs, the stakes couldn't be higher