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Participants who faced access issues reported a 13.7% weight loss within 12 months and a 14.9% loss within 24 months, on average
Clinical trials define constipation strictly, typically as fewer than three bowel movements per week
Although the direct inhibition of DPP-4 activity does not seem to regulate bone remodeling, the impact of DPP-4 on bone metabolism is indirect, involving the modulation of DPP-4 substrates and inflammation within the bone microenvironment
This allows coordinated monitoring and prompt adjustment if any issues arise
