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Because it targets two hormones, endocrinologists sometimes see greater results in people struggling to lose weight despite lifestyle measures

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doi: 10.3389/fcdhc.2025.1720794 Received 09 October 2025 Accepted 03 November 2025 Published 24 November 2025 Volume 6 - 2025 Edited by Marilena Vitale, Federico II University Hospital, Italy Reviewed by Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Gianpaolo Zerbini, San Raffaele Hospital (IRCCS), Italy Giovanna DAbbronzo, Federico II University Hospital, Italy Updates Copyright 2025 Codella, Senesi and Luzi

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some randomized controlled trials demonstrated that liraglutide, dulaglutide, semaglutide, and albiglutide reduced the rate of CV events in T2DM patients ( Another novel glucose-lowering agent is tirzepatide which has a dual mechanism of action: a GLP-1 and a glucose-dependent insulinotropic polypeptide (GIP) co-agonist