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The study further indicated that depression or anxiety decreased with increasing duration of treatment after the initiation of GLP-1 RA medication

Tirzepatide is also less effective at reducing body weight in T2D patients compared to patients without (15.7% weight loss, SURMOUNT-2 and 22.5% weight loss, SURMOUNT-1, respectively)

9 GLP-1 agonists are contraindicated during pregnancy due to safety concerns, because they restrict foetal growth when given to experimental animals

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