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Using a robust new-user, active-comparator design across 10 international databases, the investigators compared major cardiovascular outcomes, including 3-point MACE (myocardial infarction, stroke, cardiovascular death) and 4-point MACE (adding heart failure hospitalization)

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Furthermore, small molecule oral agonists such as danuglipron are also under development, highlighting the potential for improved patient compliance through non-injectable delivery forms [116]

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