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Although clinically effective, they are associated with significant metabolic side effects, including increased insulin resistance, impaired function of pancreatic -cells, and, finally, weight gain

Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review

It also: Suppresses lipolysis (fat breakdown) Inhibits hepatic ketogenesis When insulin doses are reduced even slightly the liver may increase ketone production

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Uninsured patients often discover that tax-advantaged savings accounts cover GLP-1 therapy, effectively reducing out-of-pocket costs beyond the base monthly price