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Thats how GLP-1 agonists work to control blood sugar in diabetic patients

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Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor

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doi: 10.1210/en.2016-1234 64 TanMChengYZhongXYangDJiangSYeYet al

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Print this

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It will be regulated by the FDA and used as a legitimate treatment

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