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Description
Estrogen and GLP-1 signaling appear to reinforce one another in the brain regions that govern hunger and reward, which may make appetite suppression land harder in women

Early initiation of metformin treatment plus an SGLT-2 inhibitor is recommended in most people with type 2 diabetes, followed by the addition of glucose-lowering agents as needed to achieve individualised glycaemic targets (Table 2)

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Transparency Declaration: The authors confirm that the manuscript is an honest, accurate, and transparent account of the study being reported
