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Estrogen and GLP-1 signaling appear to reinforce one another in the brain regions that govern hunger and reward, which may make appetite suppression land harder in women

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Early initiation of metformin treatment plus an SGLT-2 inhibitor is recommended in most people with type 2 diabetes, followed by the addition of glucose-lowering agents as needed to achieve individualised glycaemic targets (Table 2)

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Transparency Declaration: The authors confirm that the manuscript is an honest, accurate, and transparent account of the study being reported

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