glp-1 drugs oral GLP-1s rapidly expanding user base Could a once-a-day pill replace

found that GLP-1R activation reduced tumor growth and metastatic potential by inhibiting ERK1/2 and AKT phosphorylation, lowering MMP-2 and MMP-9 expression, and increasing E-cadherin

26 luglio 2019 [citato 5 giugno 2024];2(4):e00082

Endocrinol Diabetes Metab (2020) 3(3):e00163

Comparative studies and head-to-head trials are essential for understanding the distinct attributes of each GLP-1 RA, shedding light on their efficacy, dosing, and side effects to better tailor treatment plans to individual patient needs

67,68 Still, the presence of GLP-1 RA-specific psychiatric adverse events that may also be related to drug intolerance requires the development of a strategy to overcome this barrier for the better implementation of GLP-1RA therapy