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While GLP-1s clearly are effective for weight loss, experts may be concerned if their patients do not make other lifestyle changes, for example, changing their diet or being more active

In animal studies, this drug not only directly activates GLP-1 receptors in the hypothalamus and brainstem but also indirectly modulates neuronal circuits in other regions involved in eating behavior, such as the lateral parabrachial nucleus

Curious how others in pharmacy, hepatology, and managed care are thinking about durability of response as MASLD treatments evolve

This trend has also caused an increase in off-label use, where the drug is prescribed for something other than its approved use

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