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Description
While most patients tolerate GLP-1 injections well, common side effects like nausea, vomiting, diarrhea, and constipation tend to improve over time
The compounds full efficacy unfolds over many months of consistent escalation and maintenance
Compared to the use of GLP1-RAs alone, the combination of SGLT2is and GLP1-RAs was associated with a 30% reduction in the risk of MACE, with rates of 7.0 versus 10.3 events per 1000 person-years (HR 0.70
Both compounds cause primarily gastrointestinal side effects that peak during dose escalation
Ahmed GU et al
