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These include: Pancreatitis Increased heart rate An increased risk of gallbladder disease Low blood sugar (hypoglycemia) Kidney problems Increased risk of thyroid cancer or tumors Allergic reactions like skin rash, swelling, breathing difficulties Talk to your healthcare provider right away if you experience any side effects while taking oral semaglutide or semaglutide injections

Does split dosing affect how long semaglutide stays in my system

However, insurance coverage can be trickier since its specifically for weight loss rather than diabetes management

Tirzepatide, the active ingredient in Zepbound and Mounjaro, also mimics GLP-1 plus another gut hormone known as GIP

Last medically reviewed: May 2026 Find the right provider for your needs select your state to find expert care near you.