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Some reach their target weight and shift focus to weight maintenance rather than continued loss

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Red flag symptoms requiring urgent medical attention include: Severe, persistent abdominal pain (potential pancreatitis) contact your GP urgently, call NHS 111, or attend A&E if severe Signs of dehydration from vomiting or diarrhoea contact your GP or NHS 111 promptly Rapidly enlarging lymph nodes contact your GP or haematology team urgently Unexplained bruising or bleeding contact your GP or haematology team urgently Severe fatigue or breathlessness seek urgent medical advice via GP, NHS 111, or A&E if severe Sudden changes in vision seek urgent medical attention, particularly if you have diabetes with pre-existing retinopathy Shared decision-making is paramount

Uptake by BMECs after IR-EM-binding peptide (IEP) blockade BMECs were preseeded in 12-well plates (2 10 5 per well) and cultured at 37 C for 24 h, after which the medium was discarded, and fresh medium added that contained IEP at final IEP concentrations of 0.8%, 0.4%, and 0.2% (molar ratio) of the phospholipids, and the cells were then incubated for 1 h

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