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Since the approval of semaglutide for weight loss in 2021, widespread use of GLP-1 receptor agonists has skyrocketed

With subcutaneous semaglutide treatment at steady state (1.0 mg), the pharmacokinetics of metformin, warfarin, atorvastatin and digoxin, and the bioavailability of the combined oral contraceptive, ethinylestradiol/levonorgestrel, were not affected to a clinically relevant degree with semaglutide co-administration.35,55 Semaglutide affected population pharmacokinetic model parameters of paracetamol and atorvastatin in healthy subjects

Ideal sublingual candidates are small (under 1,000 daltons), lipophilic (able to cross cell membranes easily), and require low doses

Ozempic can now be used to lower the risk of CKD progression, kidney failure, and cardiovascular-related death in that patient population

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