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These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored

Though generally well-tolerated, GLP-1 receptor agonists commonly cause gastrointestinal disturbances during the initial treatment phase

Understanding your own needs and priorities will help guide the conversation with your doctor and ensure that GLP-1 therapy is the right choice for you

It works by slowing gastric emptying and enhancing satiety signals, which leads to reduced calorie intake