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The LEADER trial demonstrated a 13% reduction in MACE with liraglutide in high-risk patients with T2D

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In contrast, the pharmacological nanomolar concentrations of GLP-1RAs predominantly activate the cAMP/PKA pathway, potentially explaining their broader therapeutic effects [122]

The resultant sections were then segmented further, with one component designated for drying and neutron activation for determination of microsphere counts, and another for flash freezing in liquid nitrogen for proteomic profiling