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48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia

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[1] Patients who persist through the initial symptomatic period typically achieve stable bowel patterns compatible with normal daily activities

FDA Approval and Proven Real-World Safety Semaglutide is fully FDA-approved under two branded formulations Ozempic for type 2 diabetes and Wegovy for chronic weight management with years of post-market safety data covering millions of patients globally

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