oral glp 1 agonist for type 2 diabetes GLP-1 Drug Savings: A Complete Guide How to Save on Ozempic, Wegovy, and More GLP-1 Receptor Agonists as Treatments

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49 LiQ.ZhaoY.GuoH.LiQ.YanC.LiY.et al (2023)

Current and emerging therapies act on key metabolic pathways: 1) hepatospecific activation of thyroid hormone receptor (THR) to increase -oxidation and reduce lipogenesis (resmetirom)

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Employing preclinical, ex vivo, in vivo, and in vitro model systems investigators determined that GLP-1 agonists exert anti-inflammatory and immune modulating effects through their effects on macrophages (reduced interleukin [IL] 1, IL-6, tumor necrosis factor [TNF], and C-X-C motif chemokine ligand [CXCL]), T and B lymphocytes (reduced cluster of differentiation [CD] 4 cells), monocytes (increased IL-10), mononuclear cells (decreased monocyte chemoattractant protein [MCP]1, cell death protein [PD],, CD4 and CD8 T cells) [5155]