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Moreover, consistent with the increase in PPAR and CD36 expression 25,26 , P5 chronic treatment significantly increased the number of small adipocytes in eWAT without decreasing net body fat suggesting that the G-protein-biased agonist promotes de novo differentiation of preadipocytes which reside in the stromal vascular fraction of adipose tissue

Overview of the Chemistry, Pharmacokinetic Profiles, and Pharmacodynamic Mechanisms of DPP4 Inhibitors DPP4is are a diverse group of small molecules that vary in their chemical structure, pharmacokinetic properties, including absorption, distribution, metabolism, and excretion pathways, and pharmacodynamic attributes, such as the potency and selectivity of DPP4 inhibition [66, 71, 72]

[DOI] [PubMed] [Google Scholar] 4.Nauck M.A., Quast D.R., Wefers J., Meier JJ
