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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

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Best combined with mindful eating and regular activity

The lead study author and doctors share how these unknown side effects can impact your training and the best ways to adjust your workout routine when taking a GLP-1.