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In vitro studies show that GLP-1 receptor activation can improve sperm motility through a mechanism that does not depend on insulin signaling, and can enhance the metabolic activity of Sertoli cells the cellular scaffolding on which spermatogenesis depends

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More advanced cases of obesity or diabetes may need higher doses, though even those patients might benefit from starting low and escalating only if needed

semaglutide injections occur once weekly and do not require daily timing coordination