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They can submit it with the authorization request.5

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Anyone experiencing adverse effects should contact their GP or NHS 111 promptly, or attend A&E if symptoms are severe

Unlike MC4R-targeted agonists such as setmelanotide, whose efficacy is intrinsically limited by the functional status of the impaired receptor, GLP-1 RAs operate via pathways largely independent of the leptin-melanocortin circuitry

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