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Although scientists are still figuring out how allulose lowers blood sugar and helps with overall glycemic control, preliminary research suggests that the sweetener may improve insulin sensitivity by helping a liver enzyme called glucokinase work more effectively

(13) Additionally, GLP-1 signaling may help suppress pro-inflammatory pathways, reducing the chronic low-grade inflammation associated with both obesity and bone loss

This likely explains the large heterogeneity in observed lesions in kidney biopsies in the T2D population

From a mechanistic perspective, hypersensitivity with retatrutide may reflect the immune system reacting to a synthetic peptide sequence, a phenomenon not unique to this drug

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