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Who Should Not Be Included in Research Protocols Using These Compounds Research exclusion criteria documented in clinical trials for both compounds include subjects with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, and severe gastrointestinal disease [5][8]

Retatrutide decreased mean SBP by up to 12.1 mmHg in persons with overweight/obesity not having uncontrolled hypertension [50], improving on results reported for tirzepatide [51] and semaglutide [52]

Focus on protein: Consuming high-quality protein helps preserve muscle mass and supports the medications appetite regulating effects