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11 Sitagliptin is a minor substrate for the cytochrome P450 system, and drug interactions are limited to concomitant use with digoxin

Rubino et al., Diabetes, Obesity and Metabolism 2025 meta-analysis of GI tolerability across SURMOUNT-1 to -4

doi:10.36849/JDD.6550 INTRODUCTION Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that was FDA-approved in 2017 for treatment of type II diabetes and in 2021 for treatment for chronic weight management in adults with obesity or overweight with at least one weight-related condition

Fibroblasts from passages three to five were used in the experiments

Peptide chains represent polypeptide chains