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Bloating and Abdominal Pressure Bloating is the second most common complaint

99-101 Some evidence suggests long-term berberine use, especially at high doses, may impair some aspects of cellular metabolism in specific types of cells

As mentioned, protein aggregates can provoke immune responses

Others may contain undisclosed ingredients that could interact with medications you are already taking

The compounds are too big to pass the stomach wall, so they cannot be taken via the mouth (i.e
