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Proestrus is defined by large proportions of small nucleated epithelial cells (SNEs), but low numbers of leukocytes (LEUs), large nucleated epithelial cells (LNEs), and non-nucleated keratinized epithelial cells (AKEs)

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Understanding these expected changes helps distinguish normal responses from concerning developments requiring medical attention

doi: 10.1038/nn.3767

Some research also suggests that GLP-1 receptor agonists may affect gallbladder contractility, potentially contributing to bile stagnation