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4,5,6 Since 2008, the Food and Drug Administration (FDA) and European Medicines Agency have required that new T2D pharmacotherapies undergo rigorous cardiovascular safety clinical trials using hard cardiovascular endpoints and more stringent statistical review

Six studies assessed all three eligible tirzepatide maintenance doses (5, 10 and 15 mg once-weekly), while one study included two arms with a maintenance dose of 15 mg but with two different dose-escalation regimens [18]

Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

10.1016/j.jhep.2007.06.021 156 YounossiZ

Complete Prior Authorization After your pharmacy confirms your eligibility, your healthcare provider must submit a prior authorization request to Medicare
