glp-1 sarcopenia Impact of GLP- 1 Receptor Agonist Therapy in Patients High Risk for | Current Nutrition Reports Diet, exercise, and pharmacotherapy for

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The STEP and SURMOUNT trials consistently showed 26 to 40 percent of total weight lost was lean mass

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GLP-1R overexpression can inhibit the expression of inflammatory factors such as IL-6, IL-8, TNF- and granulocyte and macrophage colony-stimulating factor (GM-CSF) by increasing the expression of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and reduce the proliferation and migration of smooth muscle, indicating that GLP-1R can play a protective role in smooth muscle cells and COPD, thereby improving airway inflammation and airflow limitation in COPD patients, providing a basis for the application of GLP-1RA in COPD

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