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Clinical trials have demonstrated that adding a GLP1-RA to patients already receiving SGLT2is is cardiovascularly safe [65] and may even reduce cardiovascular events [19]

They activate GLP-1 receptors, which then results in: Slowed gastric emptying , so you feel full for a longer period of time Decreased food noise in your brain, thereby increasing the feeling of satiety Enhanced insulin release from your pancreas, thereby lowering the amount of blood sugar in your body The weight loss benefit from these medications was found to be substantial, so in 2014, the first GLP-1 agonist (liraglutide branded as Saxenda) was approved for weight loss in non-diabetics

Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, et al

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There are multiple drug names and mechanisms, ongoing debates about who should take the drugs, questions about cost and access, and anxiety about what happens if you stop taking them