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Animal studies investigating liraglutide in a rat model of migraine led to reduced expression of calcitonin gene-related peptide and other pro-inflammatory molecules involved in pain mediation, as well as upregulation of interleukin-10 which can improve migraine-associated pain (6,25)

These include: Nausea (the most common complaint, particularly in the first few weeks) Vomiting Diarrhoea or constipation Decreased appetite (which, while therapeutically desirable, can occasionally be excessive) Abdominal discomfort or bloating Injection-site reactions (such as redness, itching, or mild swelling at the injection site) Headache, dizziness, and fatigue , particularly during early treatment These effects are generally dose-dependent and tend to diminish as the body adjusts to the medication
