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Individuals with certain allele combinations may require higher doses or may benefit from switching to a dual-peptide therapy like tirzepatide, which activates both GLP-1 and GIP pathways

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Some patients note that weight loss from semaglutide therapy reduces overall inflammatory stress on joints and muscles, which may help with fibromyalgia symptom intensity

Scientists analyzed electronic medical records for more than 73,000 people and found that after 5 years, GLP-1 use was linked to a significantly higher risk of developing osteoporosis, compared to those not taking the medication

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