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In patients with chronic kidney disease, preference is generally given to sodium-glucose co-transporter 2 (SGLT2) inhibitors, although a GLP-1 RA may be considered if SGLT2 inhibitors are contraindicated or if further glucose lowering is needed [31,32,33]
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however, RNAi knockdown data, which due to the similarity between fbf-1 and fbf-2 likely reduced the function of both genes simultaneously, suggested that these genes are likely redundant for their role in the sex determination pathway and regulation of fem-3 (Zhang et al., 1997)
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