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However, in the preplanned subgroup analysis looking only at patients who were or were not taking SGLT2 inhibitors or GLP-1RAs, the average difference in peak VO2 between the AT-001 group and the placebo group was 0.64, which was both statistically and clinically significant, Januzzi said

What the 2025 Gastroenterology Metaanalysis Found The systematic review and metaanalysis (DOI: 10.1053/j.gastro.2025.06.003) evaluated safety outcomes across randomized trials and realworld studies of GLP1 RAs

Address obesity and all comorbidities.

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We summarize the effects of semaglutide, dosages utilized, potential negative outcomes, and users' before-and-after results.