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When GLP-1 reaches the pancreas, it binds to GLP-1 receptors (GLP-1R) expressed on the pancreatic cells, stimulating insulin release

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Patients with a prior prescription for any GLP-1 RA during all available look-back time before the index date or with a prescription for two different study drugs on their potential index date were excluded

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Interestingly, a recent large database study presented at ENDO 2024 suggested that GLP-1s may actually reduce the risk of recurrent pancreatitis in people with obesity and type 2 diabetes compared with some other diabetes drugs

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