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Funding Funding was provided by Novo Nordisk which manufactures semaglutide

doi: 10.1016/j.physbeh.2019.04.008

Furthermore, some researchers suggest that irisin can be considered an incretin hormone because its secretion is influenced by meals and increases insulin secretion in a glucose-dependent manner [23]

The findings from this review suggest that semaglutide induces a weight reduction of approximately 12% every 10 weeks in patients with T2DM and is more effective than other GLP-1 RAs, with the exception of tirzepatide, which is more efficacious

These medications particularly benefit patients with a BMI of 30 or more, who face four to five times higher risk of heart disease, stroke, and diabetes 2