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Description
While there are no head-to-head trials specifically designed to compare tirzepatide plus metformin versus tirzepatide alone for weight loss, the available evidence suggests the combination is safe and effective, with metformin providing additional metabolic benefits without diminishing tirzepatide's weight loss effects

SURMOUNT-1 enrolled adults with obesity or overweight without diabetes
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Injection site reactions (redness, itching, swelling) may occur and are typically mild and transient

Not all patients require maximum dosing, and some achieve optimal results at intermediate doses
